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CONSTANTINE A. TOUMBIS, M.D., Ph.D.

EDUCATION

POST GRADUATE

Spinal Surgery Fellow, Cleveland Clinic Foundation:  The Spine Institute, Weston, Florida, (July, 2004-July, 2005).

Orthopaedic Surgery Resident, University of Florida Department of Orthopaedic Surgery, Jacksonville, Florida, (June,1999-June, 2004).

Surgical Intern, University of Florida Department of Surgery, Jacksonville, Florida, (June, 1998-June,1999). 

 GRADUATE

Wayne State University School of Medicine, Detroit, Michigan (1994-1998).

            M.D. with Distinction in Biomedical Research, awarded 6/98.

Roswell Park Graduate Division of Science, State University of New York at Buffalo, Department of Experimental Pathology (1988-1993).

Ph.D. in Experimental Pathology awarded in 6/93 (thesis defense 3/26/93).

M.S. in Natural Sciences awarded in 9/88.

 UNDERGRADUATE

New York University, Washington Square College of Arts and Science (1984-1987).  Bachelor of Arts, awarded in 5/87.  Major:  Biology.

  ACADEMIC AND OTHER APPOINTMENTS

Post Doctoral Research Associate, Albert Einstein College of Medicine, Chanin Cancer Research Center, Bronx, New York (August 1993-August 1994).

Adjunct Assistant Professor of Biology, Yeshiva University, New York, New York   (1993-1994).

Instructor in Biology, Canisius College, Buffalo, New York (1992-1993).

Research Assistant, Hemex Corporation, Buffalo, New York (1989-1993).

Wayne State University School of Medicine Curriculum Committee (1994-1998).

Wayne State University School of Medicine Faculty Promotion and Tenure Committee (1995, 1996).

Wayne State University School of Medicine Course Evaluation Committee, Coordinator for both Year I and Year II (1994-1996).

Wayne State University School of Medicine Year II Curriculum Committee (1995-1996).

AWARDS

 Florida Orthopaedic Society, 52nd Annual Meeting: First Place:  Outstanding Scientific Paper,     5/99.

M.D. with Distinction in Biomedical Research, 6/98

Wayne State University School of Medicine Year II Research Achievement Commendation, Honors/Awards Ceremony, 1996.

Wayne State University School of Medicine Research Symposium, second place, oral competition, 1995.

Medical Student Research Fellowship (awarded through the Wayne State University Alumni Foundation and the Department of Orthopaedic Surgery), 1994.

National Institute of Health Post-Doctoral Training Fellowship (awarded through the Albert Einstein College of Medicine).

New York University Trustee Scholarship (1983-1987).

New York State Regents Scholarship

MEDICAL LICENSURE

USMLE Step I:   passed 6/96

USMLE Step II:  passed 8/97

USMLE Step III: passed 5/99

Licensed in the State of Florida since 2000, License #:  ME0080012

 TEACHING EXPERIENCE

Adjunct Assistant Professor of Biology, Yeshiva University, New York, New York.  
            Courses:  Introduction to Biology.  1993-1994.

Instructor in Biology, Canisius College, Buffalo, New York. 
            Courses:  Vertebrate Anatomy and Physiology Laboratories.  1992-1993.

Lecturer, SUNY @ Buffalo Graduate Division. 
            Principal assistant to Professor Julian L. Ambrus, M.D., Ph.D..  1988-1992.
            Courses:  Pathophysiology, Geographic Pathology, Endocrinology,            

Hematology/Oncology.

Assistant Advisor for Roswell Park Cancer Institute Summer Research Program.

Designed project for summer research student.  Supervised research and progress during summer research program which culminated in research poster presentation and lecture by summer student (6/91-8/91).

Invited Lecturer for NATO Annual Seminar on Angiogenesis (5/91). Presented original    research on corneal angiogenesis performed in the laboratory of Dr. Julian L. Ambrus to scientists at this international conference.  Represented the Roswell Park Cancer Institute in the seminar and presented research performed at the Roswell Park Cancer Institute. 

PUBLICATIONS

Toumbis, C.A., Gearen, P., Fiolkowski, P., Conrad, B., Myers, S., and Wheeler, D.L.:  Effect of Preparation of Low and High-Dose Vancomycin and Tobramycin on the Ultimate Tensile Load of Antibiotic-Impregnated PMMA Cement. Submitted on 10/2002 to JBJS, American Edition.

Wheeler, D.L., Eschbach, E.J., Reeves, J.D., Rose, A.T., Toumbis, C.A., Lewis, D.D., Cross, A.T.:  Enhanced Osteointegration by Protein-Spiked Polymer Coatings.  Accepted for publication to the Journal of Biomedical Materials Research.  Publication pending in 2002. 

Toumbis, C.A., Caler, W., Tejwani, N., Henley, B., Agnew, S.G., Segina, D.,:  Antegrade Versus Retrograde Intramedullary Fixation of Femoral Shaft Fractures:  A Biomechanical Study.  Journal of the Florida Orthopaedic Society, Spring 2002.

Toumbis, C.A., Kronick, J.L., Wooley, P.H., and Nasser, S.:  Total Joint Arthroplasty and the Immune Response.  Department of Orthopaedic Surgery Wayne State University School of Medicine, Detroit, Michigan.   Seminars in Arthritis and Rheumatism, August, 1997.

Toumbis, C.A. and Nasser, S.:  Letter to the Editor; Informing Patients About Total Hip Arthroplasty.  JAMA, December 18th, 1996, volume 276, No. 23, p. 1875.

Toumbis, C.A.:  Letter to the Editor; A Right to Medical Education?  American Medical News.  Sept. 16th, 1996, volume 39, number 35.

Stadler, I., Toumbis, C.A., and Ambrus, J.L.:  Influence of Cold Storage Altered Red Cell Surface on the Function of Platelets.  Journal of Medicine, vol. 24, no. 6, pp. 353-361, 1995.

Ambrus, J.L., Ambrus, C.M., Stadler, S., Toumbis, C.A., Markus, G.:  Potentiation of thrombolytic therapy by enzyme combinations and with aspirin or pentoxifylline.  Journal of Medicine, vol. 25, nos. 3 and 4, pp. 145-163, 1994.

Stadler, S., Chadha, K.C., Nakeeb, S., Toumbis, C.A., Butsch, J., Mathur, N., Munschauer, F., Vladiutu, A., Satchidanand, S.K., and Ambrus, J.L.:  Pentoxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine model of AIDS.  The Journal of Pharmacology and Experimental Therapeutics, vol. 268, no. 1, 1994. 

Toumbis, C.A., Stadler, S., Ambrus, J.L.:  Effect of Red Blood Cells from Patients with Sickle Cell Disease on Platelet Factor 3 Release.  American Journal of Hematology, 40:  149-150, 1992.

Ambrus, J.L., Ambrus, C.M., Toumbis, C.A., Forgach P., Karakousis, C.P., Niswander, P., Lane, W.:  Studies on tumor-induced angiogenesis.  Journal of Medicine, vol. 22, no. 6, pp. 355-369, 1992.

BOOK CHAPTERS

Ambrus, J.L., Ambrus, C.M., Toumbis, C.A., Forgach, P., Karakousis, C.P., Niswander, P.:  Tumor induced angiogenesis.  Effect of platelet derived growth factor (PDGF), pentoxifylline, sodium diethyldithiocarbamate, epsilon amino caproic acid and transaxemic acid.  Angiogenesis in Health and Disease, Plenum Press, New York, 1992.

Ambrus, J.L., Ambrus, C.M., Forgach, P., Stadler, S., Halpern, J., Sayyid, S., Niswander, P., Toumbis, C.A.:  Studies on tumor induced angiogenesis. Proceedings of the Angiogenesis Symposium, Angiogenesis:  Key Principles-Science-Technology-Medicine, St. Gallen, Switzerland, pp. 436-444, 1992.  Edited by R. Steiner, Birkhauser Verlag Basel/Switzerland.  

ABSTRACTS

Segina, D.N., Toumbis, C.A., Henley, B., Agnew, S.G., Caler, W.:  Antegrade versus Retrograde Intramedullary Fixation of Femoral Shaft Fractures:  A Biomechanical Study.  Orthopaedic Trauma Association (OTA) for the 2001 Annual Meeting.

Segina, D.N., Toumbis, C.A., Henley, B., Agnew, S.G., Caler, W.:  Antegrade versus Retrograde Intramedullary Fixation of Femoral Shaft Fractures:  A Biomechanical Study.  Submitted to and accepted by the Florida Orthopaedic Society (FOS) 2001 Annual Meeting.

Toumbis, C.A., Myers, S., Gearen, P., Conrad, B., Wheeler, D.:  Methods of Preparation Using Low- and High-Dose Vancomycin and Tobramycin and their Effect on the Ultimate Tensile Strength of Antibiotic-Impregnated PMMA Cement. Department of Orthopaedics and Rehabilitation, College of Medicine, University of Florida, Shands Jacksonville and Gainesville, Florida. Submitted to and accepted by the Florida Orthopaedic Society for the 2000 meeting, West Palm Beach, Florida.

Toumbis, C.A., Myers, S., Gearen, P., Conrad, B., Wheeler, D.:  Effect of Preparation of Low- and High-Dose Vancomycin and Tobramycin on the Ultimate Tensile Strength of Antibiotic-Impregnated PMMA Cement. Department of Orthopaedics and Rehabilitation, College of Medicine, University of Florida, Gainesville, Florida. Submitted to and accepted by the American Orthopaedic Association Resident Symposium, St. Louis, MO, February 27, 2000.

Conrad, B., Toumbis, C.A., Myers, S., Gearen, P., Wheeler, D.:  Effect of Preparation of Low- and High-Dose Antibiotics on the Ultimate Tensile Load of Antibiotic-Impregnated PMMA. Department of Orthopaedics and Rehabilitation, College of Medicine, University of Florida, Gainesville, Florida.  Accepted by the Orthopaedic Research Society 2000 Annual Meeting, Orlando, Florida, March, 2000.

Wheeler, D.L., Eschbach, E.J., Reeves, J.D., Rose, A.T., Toumbis, C.A., Cross, A.R.:  Protein-spiked Polymer Implant Coatings:  In Vitro and In Vivo Evaluation. Department of Orthopaedics and Rehabilitation, College of Medicine, University of Florida, Gainesville, Florida. Accepted by the Sixth World Biomaterials Congress, Hawaii, May 2000.

Conrad, B., Toumbis, C.A., Myers, S., Gearen, P., Rose, A.T., Wheeler, D.:  Effect of Preparation of Low- and High-Dose Vancomycin on the Ultimate Tensile Strength of Antibiotic-Impregnated PMMA Cement. Department of Orthopaedics and Rehabilitation, College of Medicine, University of Florida, Gainesville, Florida. Submitted to Sixth World Biomaterials Congress, Hawaii, May 2000.

Toumbis, C.A., Wooley, P.H., and Nasser, S.:  An Animal Model of Rheumatoid Arthritis:  The T-Cell Repertoire in Inflammatory Joint Disease.  Accepted at The Michigan Orthopaedic Society, 1997 Annual Meeting, Boyne Highlands, Michigan, June 18-21, 1997. 

Toumbis C.A., Wooley, P.H., Mayton, L., Sud, S. and Nasser, S.:  Synergistic Inflammatory Responses to Metallic and Polymeric Particles in the Murine Air Pouch Model of Aseptic Loosening.  Department of Orthopaedic Surgery, Wayne State University Medical School, Detroit, Michigan.  The Mid-America Orthopaedic Association, 1997 Annual Meeting.

Toumbis, C.A., Sud, S., Wooley, P.H., and Nasser, S.:  The T-Cell Repertoire in Pristine-Induced Arthritis.  Accepted at the Mid-America Orthopaedic Association Fifteenth Annual Meeting, Hilton Head Island, South Carolina, April 23-27, 1997.

Toumbis, C.A., Wooley, P.H., and Nasser, S.:  The T-Cell Repertoire in Pristine-Induced Arthritis.  Accepted at the Grace Hospital Annual Research Day, Grace Hospital, Detroit, Michigan, April 9th, 1997.

Toumbis, C.A., Sud, S., Wooley, P.H., and Nasser, S.:  The T-Cell Repertoire in Pristine-Induced Arthritis. Tenth Annual Pederson Day Orthopaedics Conference at the Wayne State University School of Medicine, 1996 annual meeting.

Toumbis, C.A., Sud, S., Wooley, P.H., and Nasser, S.:  The T-Cell Repertoire in Pristine-Induced Arthritis.  Accepted and presented at the 37th Annual National Student Research Forum at  The University of Texas Medical Branch at Galveston, April 25-27, 1996.

Toumbis, C.A., Sud, S., Wooley, P.H., and Nasser, S.:  The T-Cell Repertoire in Pristane-Induced Arthritis.  Accepted and Presented at the 1995 Wayne State University School of Medicine Medical Student Research Symposium.

Toumbis, C.A., Ambrus, J.L., Stadler, S., Nakeeb, S., Chadha, K.:  Pentoxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine modell of AIDS. Accepted and Presented at the 1994 Wayne State University School of Medicine Medical Student Research Symposium.

Toumbis, C.A., Little, R.D., Galgano, P.G., and Schildkraut, C.:  Replication patterns of Epstein Barr Virus (EBV) and their relationship to oncogenesis.  Accepted at the 1994 American Association of Cancer Research Symposium (AACR).  1994 Proceedings of the AACR.

Ambrus, J.L., Stadler, S., Nakeeb, S., Toumbis, C.A., Butsch, J., Spatola, F., Mathur, N., Munschauer, R., Chada, K.:  Biochemical changes in Kaposi’s Sarcoma and experimental therapy of murine AIDS.  1993 Proceedings of the AACR.

Ambrus, J.L., Ambrus, C.M., Stadler, S., Toumbis, C.A.:  Potentiation of thrombolytic eggect by enzyme combinations and by aspirin (ASA) or pentoxifylline (P). Proceedings of the 14th Congress of International Thrombosis and Haemostasis, 1993.

Ambrus, C.M., Stadler, I, Toumbis, C.A., Stadler, A., Anthone, S., DeAlarcon, P., Deshpande, M., Conway, J., and Vladutiu, A.L.:  removal of Non-Transferrin Bound Iron with Immobilized Desferrioxamine from Blood with Iron Overload.  Proceedings of the American Society of Hematology 35th Annual Meeting, 1993.

Toumbis, C.A., Butsch, J.L., Smith, C.A., Stadler, I., Vladutiu, A., Ambrus, J.L.:  A comparison of platelet activation in pregnant women and in the cord blood of their fetuses.  Proceedings of the 14th Congress of International Thrombosis and Haemostasis, 1993.

Ambrus, J.L., Ambrus, C.M., Toumbis, C.A., Forgach, P., Karakousis, C.:  Tumor induced angiogenesis in a primate model.  Effect of platelet derived growth factor (PDGF), pentoxifylline and sodium diethyldithiocarbamate (DDTC).  The NATO meeting of Angiogenesis in Health and Disease, Porto Hydra, Greece, 1991.

REVIEW ARTICLES (not peer reviewed)

Toumbis, C.A.:  The resurgence of Tuberculosis.  Health Magazine and Hospital News, vol. 5, no. 13, January 1992.

Toumbis, C.A. and Smith, C.A.:  Oral Cavity Cancer-Diagnosis and Treatment.  Health Magazine and Hospital News, vol. 6, no. 3, March, 1992.

Toumbis, C.A. and Smith, C.A.:  Applying Common Sense in the Cholesterol Fight.  Health Magazine and Hospital News, vol. 6, no. 5, May, 1992. 

Toumbis, C.A.:  Criteria used for the Diagnosis of Rheumatoid Arthritis.  Health Magazine and Hospital News, vol. 6, no. 5, May, 1992. 

Toumbis, C.A. and Smith, C.A.:  Plastic and Reconstructive Surgery.  Health Magazine and Hospital News, vol. 6, no. 6, June 1992.

Toumbis, C.A. and Smith, C.A.:  PET Scans Applied in Psychiatric Studies.  Health Magazine and Hospital News, vol. 6, no. 12, December, 1992.

Toumbis, C.A.:  Diabetic Eye Disease.  Health Magazine and Hospital News, vol. 5, no. 12, December, 1991.

BOOK REVIEWS

Toumbis, C.A.:  The Pathology of the Aging Human Nervous System.  The Journal of Medicine, vol. 22, no. 3, 1991.